Drug interactions
Chloramphenicol + Paclitaxel protein bound
Severity: Moderate
Chloramphenicol and Paclitaxel protein bound: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paclitaxel is partly cleared by CYP3A4 and CYP2C8, so chloramphenicol may increase exposure. This could worsen neutropenia and peripheral neuropathy.
What this interaction means in plain words
Chloramphenicol and Paclitaxel protein bound can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chloramphenicol inhibits CYP3A4 (and possibly CYP2C8), reducing paclitaxel clearance.
What to do
Monitor blood counts and neuropathy closely, and reduce the paclitaxel dose if toxicity develops. Chloramphenicol is also myelosuppressive, so consider an alternative antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chloramphenicol and Paclitaxel protein bound, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Chloramphenicol
Frequently asked questions
Can I take Chloramphenicol with Paclitaxel protein bound?
MediHelp rates the interaction as moderate. Chloramphenicol and Paclitaxel protein bound can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paclitaxel is partly cleared by CYP3A4 and CYP2C8, so chloramphenicol may increase exposure. This could worsen neutropenia and peripheral neuropathy.
How serious is the interaction between Chloramphenicol and Paclitaxel protein bound?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy closely, and reduce the paclitaxel dose if toxicity develops. Chloramphenicol is also myelosuppressive, so consider an alternative antibiotic.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
