Drug interactions
Chloramphenicol + Pirtobrutinib
Severity: Major
Chloramphenicol and Pirtobrutinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pirtobrutinib is a CYP3A4 substrate, and chloramphenicol may raise its exposure. This could increase adverse effects such as bleeding, infection and cytopenias.
What this interaction means in plain words
Chloramphenicol and Pirtobrutinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloramphenicol belongs to Anti Bacterial; Pirtobrutinib belongs to Oncology.
Why it happens
Chloramphenicol inhibits CYP3A4, reducing pirtobrutinib clearance.
What to do
Prefer a different antibiotic. If unavoidable, reduce the pirtobrutinib dose per labeling and monitor blood counts and for bleeding or infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chloramphenicol
Other interactions of Pirtobrutinib
Frequently asked questions
Can I take Chloramphenicol with Pirtobrutinib?
MediHelp rates the interaction as major. Chloramphenicol and Pirtobrutinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pirtobrutinib is a CYP3A4 substrate, and chloramphenicol may raise its exposure. This could increase adverse effects such as bleeding, infection and cytopenias.
How serious is the interaction between Chloramphenicol and Pirtobrutinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a different antibiotic. If unavoidable, reduce the pirtobrutinib dose per labeling and monitor blood counts and for bleeding or infection.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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