Drug interactions
Chloramphenicol + Ropeginterferon alfa 2b
Severity: Major
Chloramphenicol and Ropeginterferon alfa 2b: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can suppress bone marrow function. Together they may cause additive anemia, leukopenia and thrombocytopenia.
What this interaction means in plain words
Chloramphenicol and Ropeginterferon alfa 2b can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic myelosuppression.
What to do
Avoid the combination where possible and use a non-myelosuppressive antibiotic. If used, monitor complete blood counts frequently and stop or reduce therapy if cytopenias develop.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chloramphenicol
Frequently asked questions
Can I take Chloramphenicol with Ropeginterferon alfa 2b?
MediHelp rates the interaction as major. Chloramphenicol and Ropeginterferon alfa 2b can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can suppress bone marrow function. Together they may cause additive anemia, leukopenia and thrombocytopenia.
How serious is the interaction between Chloramphenicol and Ropeginterferon alfa 2b?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use a non-myelosuppressive antibiotic. If used, monitor complete blood counts frequently and stop or reduce therapy if cytopenias develop.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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