Drug interactions
Chloramphenicol + Sofosbuvir / velpatasvir
Severity: Minor
Chloramphenicol and Sofosbuvir / velpatasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir is partly metabolized by CYP3A4, so chloramphenicol could modestly raise its exposure. A clinically significant effect is not expected.
What this interaction means in plain words
Chloramphenicol and Sofosbuvir / velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak to moderate CYP3A4 inhibition may slightly reduce velpatasvir metabolism.
What to do
No dose adjustment is generally needed; monitor for gastrointestinal effects and headache.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chloramphenicol
Frequently asked questions
Can I take Chloramphenicol with Sofosbuvir / velpatasvir?
MediHelp rates the interaction as minor. Chloramphenicol and Sofosbuvir / velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Velpatasvir is partly metabolized by CYP3A4, so chloramphenicol could modestly raise its exposure. A clinically significant effect is not expected.
How serious is the interaction between Chloramphenicol and Sofosbuvir / velpatasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed; monitor for gastrointestinal effects and headache.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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