Drug interactions
Chloramphenicol + Tezacaftor
Severity: Moderate
Chloramphenicol and Tezacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tezacaftor is a CYP3A4 substrate, and chloramphenicol may increase its concentrations. Increased exposure could amplify adverse effects of the CFTR modulator combination.
What this interaction means in plain words
Chloramphenicol and Tezacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chloramphenicol inhibits CYP3A4 metabolism of tezacaftor.
What to do
Consider an alternative antibiotic. If co-administered, monitor for adverse effects and liver tests, and follow labeling dose adjustments for CYP3A4 inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Frequently asked questions
Can I take Chloramphenicol with Tezacaftor?
MediHelp rates the interaction as moderate. Chloramphenicol and Tezacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tezacaftor is a CYP3A4 substrate, and chloramphenicol may increase its concentrations. Increased exposure could amplify adverse effects of the CFTR modulator combination.
How serious is the interaction between Chloramphenicol and Tezacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antibiotic. If co-administered, monitor for adverse effects and liver tests, and follow labeling dose adjustments for CYP3A4 inhibitors.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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