Drug interactions
Chloramphenicol + Tofacitinib
Severity: Moderate
Chloramphenicol and Tofacitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol inhibits CYP3A4 and may raise tofacitinib exposure. Higher levels increase the risk of dose-related adverse effects such as infection and cytopenias.
What this interaction means in plain words
Chloramphenicol and Tofacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Tofacitinib belongs to Musculoskeletal.
Why it happens
Inhibition of CYP3A4-mediated metabolism of tofacitinib.
What to do
Consider reducing tofacitinib dose in line with labeling for CYP3A4 inhibitors, or choose another antibiotic. Monitor blood counts and infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Other interactions of Chloramphenicol
Frequently asked questions
Can I take Chloramphenicol with Tofacitinib?
MediHelp rates the interaction as moderate. Chloramphenicol and Tofacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol inhibits CYP3A4 and may raise tofacitinib exposure. Higher levels increase the risk of dose-related adverse effects such as infection and cytopenias.
How serious is the interaction between Chloramphenicol and Tofacitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing tofacitinib dose in line with labeling for CYP3A4 inhibitors, or choose another antibiotic. Monitor blood counts and infection.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
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