Drug interactions
Chloramphenicol + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Chloramphenicol and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol is a CYP3A4 substrate, and chloramphenicol may increase its systemic exposure. This could enhance beta-agonist effects such as tachycardia, tremor and hypokalemia.
What this interaction means in plain words
Chloramphenicol and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chloramphenicol inhibits CYP3A4 metabolism of vilanterol.
What to do
Monitor heart rate, potassium and symptoms of excess beta-agonist effect. Consider an alternative antibiotic in patients with cardiovascular disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Frequently asked questions
Can I take Chloramphenicol with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Chloramphenicol and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol is a CYP3A4 substrate, and chloramphenicol may increase its systemic exposure. This could enhance beta-agonist effects such as tachycardia, tremor and hypokalemia.
How serious is the interaction between Chloramphenicol and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, potassium and symptoms of excess beta-agonist effect. Consider an alternative antibiotic in patients with cardiovascular disease.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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