Drug interactions
Chloramphenicol + Venlafaxine
Severity: Minor
Chloramphenicol and Venlafaxine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol may modestly raise venlafaxine levels, as CYP3A4 is a minor metabolic route. Increased exposure could cause more nausea, hypertension or serotonergic effects.
What this interaction means in plain words
Chloramphenicol and Venlafaxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chloramphenicol belongs to Anti Bacterial; Venlafaxine belongs to Central Nervous System.
Why it happens
Inhibition of the minor CYP3A4 pathway of venlafaxine metabolism.
What to do
No routine adjustment is needed. Monitor blood pressure and tolerability during co-therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chloramphenicol
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Chloramphenicol with Venlafaxine?
MediHelp rates the interaction as minor. Chloramphenicol and Venlafaxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chloramphenicol may modestly raise venlafaxine levels, as CYP3A4 is a minor metabolic route. Increased exposure could cause more nausea, hypertension or serotonergic effects.
How serious is the interaction between Chloramphenicol and Venlafaxine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor blood pressure and tolerability during co-therapy.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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