Drug interactions
Chloramphenicol + Vincristine liposomal
Severity: Major
Chloramphenicol and Vincristine liposomal: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vincristine is metabolized by CYP3A4, and chloramphenicol may increase its exposure. This may heighten neurotoxicity such as peripheral neuropathy, constipation and ileus, and may add to myelosuppression.
What this interaction means in plain words
Chloramphenicol and Vincristine liposomal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Chloramphenicol inhibits CYP3A4 metabolism of vincristine.
What to do
Avoid the combination and choose another antibiotic. If unavoidable, monitor for neurotoxicity, bowel function and blood counts.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Chloramphenicol
Frequently asked questions
Can I take Chloramphenicol with Vincristine liposomal?
MediHelp rates the interaction as major. Chloramphenicol and Vincristine liposomal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vincristine is metabolized by CYP3A4, and chloramphenicol may increase its exposure. This may heighten neurotoxicity such as peripheral neuropathy, constipation and ileus, and may add to myelosuppression.
How serious is the interaction between Chloramphenicol and Vincristine liposomal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose another antibiotic. If unavoidable, monitor for neurotoxicity, bowel function and blood counts.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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