Drug interactions
Chloramphenicol + Zanubrutinib
Severity: Moderate
Chloramphenicol and Zanubrutinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol may increase zanubrutinib exposure via CYP3A4 inhibition. This may increase bleeding, cytopenias and infection risk.
What this interaction means in plain words
Chloramphenicol and Zanubrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Zanubrutinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated zanubrutinib metabolism by chloramphenicol.
What to do
Reduce zanubrutinib to the labeled lower dose with strong CYP3A4 inhibitors and monitor blood counts and bleeding. Chloramphenicol also causes myelosuppression, so monitor counts closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Zanubrutinib
Frequently asked questions
Can I take Chloramphenicol with Zanubrutinib?
MediHelp rates the interaction as moderate. Chloramphenicol and Zanubrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol may increase zanubrutinib exposure via CYP3A4 inhibition. This may increase bleeding, cytopenias and infection risk.
How serious is the interaction between Chloramphenicol and Zanubrutinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce zanubrutinib to the labeled lower dose with strong CYP3A4 inhibitors and monitor blood counts and bleeding. Chloramphenicol also causes myelosuppression, so monitor counts closely.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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