Drug interactions
Chlordiazepoxide + Chlorpheniramine
Severity: Moderate
Chlordiazepoxide and Chlorpheniramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpheniramine is a sedating first-generation antihistamine, so combined use can increase drowsiness, impair coordination and cause confusion, especially in older adults.
What this interaction means in plain words
Chlordiazepoxide and Chlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide belongs to Central Nervous System; Chlorpheniramine belongs to Respiratory.
Why it happens
Additive CNS depression from GABA-A potentiation and central H1 blockade.
What to do
Advise against driving and alcohol, and prefer a non-sedating antihistamine. Reduce doses and monitor older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Other interactions of Chlorpheniramine
Frequently asked questions
Can I take Chlordiazepoxide with Chlorpheniramine?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Chlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpheniramine is a sedating first-generation antihistamine, so combined use can increase drowsiness, impair coordination and cause confusion, especially in older adults.
How serious is the interaction between Chlordiazepoxide and Chlorpheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise against driving and alcohol, and prefer a non-sedating antihistamine. Reduce doses and monitor older patients.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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