Drug interactions
Chlordiazepoxide + Chlorzoxazone
Severity: Moderate
Chlordiazepoxide and Chlorzoxazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzodiazepines and centrally acting muscle relaxants both depress the CNS. Together they can cause marked drowsiness, ataxia, confusion and falls, and in susceptible patients respiratory depression.
What this interaction means in plain words
Chlordiazepoxide and Chlorzoxazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide belongs to Central Nervous System; Chlorzoxazone belongs to Musculoskeletal.
Why it happens
Additive CNS depression via GABAergic and central depressant effects.
What to do
Use the lowest effective doses and monitor for oversedation, especially in older adults. Counsel on avoiding alcohol and on driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlordiazepoxide and Chlorzoxazone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Chlorzoxazone
Other interactions of Chlordiazepoxide
Frequently asked questions
Can I take Chlordiazepoxide with Chlorzoxazone?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Chlorzoxazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benzodiazepines and centrally acting muscle relaxants both depress the CNS. Together they can cause marked drowsiness, ataxia, confusion and falls, and in susceptible patients respiratory depression.
How serious is the interaction between Chlordiazepoxide and Chlorzoxazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for oversedation, especially in older adults. Counsel on avoiding alcohol and on driving.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
