Drug interactions
Chlordiazepoxide + Cyclizine
Severity: Moderate
Chlordiazepoxide and Cyclizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclizine is a sedating antihistamine with anticholinergic properties, and combining it with a benzodiazepine can deepen drowsiness and impair psychomotor performance. Older or frail patients are at greater risk of confusion and falls.
What this interaction means in plain words
Chlordiazepoxide and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide belongs to Central Nervous System; Cyclizine belongs to Respiratory.
Why it happens
Additive central nervous system depression from GABA-A potentiation and central histamine H1 blockade.
What to do
Use the lowest effective doses and warn patients to avoid driving or operating machinery. Monitor older patients for oversedation and confusion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Chlordiazepoxide with Cyclizine?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclizine is a sedating antihistamine with anticholinergic properties, and combining it with a benzodiazepine can deepen drowsiness and impair psychomotor performance. Older or frail patients are at greater risk of confusion and falls.
How serious is the interaction between Chlordiazepoxide and Cyclizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and warn patients to avoid driving or operating machinery. Monitor older patients for oversedation and confusion.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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