Drug interactions
Chlordiazepoxide + Deutetrabenazine
Severity: Moderate
Chlordiazepoxide and Deutetrabenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, and deutetrabenazine commonly causes somnolence. Combined use can produce additive drowsiness and impaired alertness.
What this interaction means in plain words
Chlordiazepoxide and Deutetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide belongs to Central Nervous System; Deutetrabenazine belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects through pharmacodynamic synergy.
What to do
Monitor for excessive sedation and counsel patients to avoid driving until the response is known. Lower the dose of either drug if somnolence is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Chlordiazepoxide with Deutetrabenazine?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Deutetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, and deutetrabenazine commonly causes somnolence. Combined use can produce additive drowsiness and impaired alertness.
How serious is the interaction between Chlordiazepoxide and Deutetrabenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and counsel patients to avoid driving until the response is known. Lower the dose of either drug if somnolence is troublesome.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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