Drug interactions
Chlordiazepoxide + Doxepin
Severity: Moderate
Chlordiazepoxide and Doxepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin is a sedating tricyclic antidepressant with strong antihistamine activity. With chlordiazepoxide, additive sedation, psychomotor impairment and falls may occur, especially in older adults.
What this interaction means in plain words
Chlordiazepoxide and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide belongs to Central Nervous System; Doxepin belongs to Dermatology.
Why it happens
Additive CNS depression from GABA-A potentiation and H1 antagonism by doxepin.
What to do
Use the lowest effective doses and monitor for sedation, confusion and falls; counsel patients against driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Chlordiazepoxide with Doxepin?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin is a sedating tricyclic antidepressant with strong antihistamine activity. With chlordiazepoxide, additive sedation, psychomotor impairment and falls may occur, especially in older adults.
How serious is the interaction between Chlordiazepoxide and Doxepin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation, confusion and falls; counsel patients against driving.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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