Drug interactions
Chlordiazepoxide + Duvelisib
Severity: Moderate
Chlordiazepoxide and Duvelisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib is a CYP3A4 inhibitor and may raise chlordiazepoxide concentrations, increasing sedation and respiratory depression risk.
What this interaction means in plain words
Chlordiazepoxide and Duvelisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide belongs to Central Nervous System; Duvelisib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated metabolism of chlordiazepoxide.
What to do
Monitor for excessive sedation and reduce the chlordiazepoxide dose as needed. Consider lorazepam as an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Chlordiazepoxide with Duvelisib?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Duvelisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duvelisib is a CYP3A4 inhibitor and may raise chlordiazepoxide concentrations, increasing sedation and respiratory depression risk.
How serious is the interaction between Chlordiazepoxide and Duvelisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and reduce the chlordiazepoxide dose as needed. Consider lorazepam as an alternative.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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