Drug interactions
Chlordiazepoxide + Loxapine
Severity: Major
Chlordiazepoxide and Loxapine: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loxapine is a sedating antipsychotic, and with a benzodiazepine it may cause marked drowsiness and respiratory depression. Inhaled loxapine carries a boxed warning for bronchospasm, and benzodiazepine co-administration has been associated with excess sedation.
What this interaction means in plain words
Chlordiazepoxide and Loxapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlordiazepoxide belongs to Central Nervous System; Loxapine belongs to Central Nervous System.
Why it happens
Additive CNS and respiratory depression via GABA-A potentiation and loxapine receptor blockade.
What to do
Use the lowest effective doses and monitor sedation and respiratory status closely. Avoid the combination in patients with respiratory compromise.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Chlordiazepoxide
Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Frequently asked questions
Can I take Chlordiazepoxide with Loxapine?
MediHelp rates the interaction as major. Chlordiazepoxide and Loxapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Loxapine is a sedating antipsychotic, and with a benzodiazepine it may cause marked drowsiness and respiratory depression. Inhaled loxapine carries a boxed warning for bronchospasm, and benzodiazepine co-administration has been associated with excess sedation.
How serious is the interaction between Chlordiazepoxide and Loxapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and respiratory status closely. Avoid the combination in patients with respiratory compromise.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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