Drug interactions
Chlordiazepoxide + Maprotiline
Severity: Moderate
Chlordiazepoxide and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline is a sedating tetracyclic antidepressant, and with a benzodiazepine it adds to drowsiness and psychomotor impairment. Maprotiline lowers the seizure threshold, which is relevant in patients on benzodiazepines who may withdraw.
What this interaction means in plain words
Chlordiazepoxide and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide belongs to Central Nervous System; Maprotiline belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A potentiation and antihistaminic effects of maprotiline.
What to do
Use lowest effective doses and counsel on driving and alcohol. Avoid abrupt benzodiazepine discontinuation because of seizure risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Chlordiazepoxide with Maprotiline?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maprotiline is a sedating tetracyclic antidepressant, and with a benzodiazepine it adds to drowsiness and psychomotor impairment. Maprotiline lowers the seizure threshold, which is relevant in patients on benzodiazepines who may withdraw.
How serious is the interaction between Chlordiazepoxide and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use lowest effective doses and counsel on driving and alcohol. Avoid abrupt benzodiazepine discontinuation because of seizure risk.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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