Drug interactions
Clorazepate + Methohexital
Severity: Major
Clorazepate and Methohexital: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methohexital is a barbiturate anesthetic and with a benzodiazepine can produce additive sedation and respiratory depression. Hypotension and airway compromise may occur.
What this interaction means in plain words
Clorazepate and Methohexital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clorazepate belongs to Central Nervous System; Methohexital belongs to Central Nervous System.
Why it happens
Additive GABA-A mediated CNS and respiratory depression.
What to do
Use in monitored settings, titrating methohexital to effect with lower doses. Ensure airway and ventilation support are available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Methohexital
Frequently asked questions
Can I take Clorazepate with Methohexital?
MediHelp rates the interaction as major. Clorazepate and Methohexital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Methohexital is a barbiturate anesthetic and with a benzodiazepine can produce additive sedation and respiratory depression. Hypotension and airway compromise may occur.
How serious is the interaction between Clorazepate and Methohexital?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use in monitored settings, titrating methohexital to effect with lower doses. Ensure airway and ventilation support are available.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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