Drug interactions
Chlordiazepoxide + Mitotane
Severity: Moderate
Chlordiazepoxide and Mitotane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a strong CYP3A4 inducer and may lower chlordiazepoxide concentrations, reducing its anxiolytic or anticonvulsant effect. Enzyme induction can persist for weeks after mitotane is stopped.
What this interaction means in plain words
Chlordiazepoxide and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide belongs to Central Nervous System; Mitotane belongs to Oncology.
Why it happens
Induction of CYP3A4 by mitotane increases chlordiazepoxide metabolism.
What to do
Monitor clinical response and increase the chlordiazepoxide dose if needed. Watch for withdrawal or reduced effect and reassess the dose after mitotane is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Chlordiazepoxide with Mitotane?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitotane is a strong CYP3A4 inducer and may lower chlordiazepoxide concentrations, reducing its anxiolytic or anticonvulsant effect. Enzyme induction can persist for weeks after mitotane is stopped.
How serious is the interaction between Chlordiazepoxide and Mitotane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and increase the chlordiazepoxide dose if needed. Watch for withdrawal or reduced effect and reassess the dose after mitotane is stopped.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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