Drug interactions
Chlordiazepoxide + Quetiapine
Severity: Moderate
Chlordiazepoxide and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are sedating, so together they can cause marked somnolence, dizziness and orthostatic hypotension. Falls and impaired alertness are the main concerns, particularly in older adults.
What this interaction means in plain words
Chlordiazepoxide and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide belongs to Central Nervous System; Quetiapine belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A potentiation and quetiapine's histamine H1 and alpha-1 adrenergic antagonism.
What to do
Start low, titrate slowly and monitor sedation and orthostatic blood pressure. Counsel against driving until tolerance is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Chlordiazepoxide with Quetiapine?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are sedating, so together they can cause marked somnolence, dizziness and orthostatic hypotension. Falls and impaired alertness are the main concerns, particularly in older adults.
How serious is the interaction between Chlordiazepoxide and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start low, titrate slowly and monitor sedation and orthostatic blood pressure. Counsel against driving until tolerance is known.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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