Drug interactions
Chlordiazepoxide + Sufentanil
Severity: Major
Chlordiazepoxide and Sufentanil: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concomitant benzodiazepine and potent opioid use can cause profound sedation, respiratory depression, coma and death. Regulatory agencies have issued boxed warnings for this combination.
What this interaction means in plain words
Chlordiazepoxide and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlordiazepoxide belongs to Central Nervous System; Sufentanil belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression through opioid receptor agonism and GABA-A potentiation.
What to do
Reserve the combination for cases without alternatives, using the lowest doses and shortest duration. Continuously monitor respiration and sedation, with resuscitation equipment available in procedural settings.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Chlordiazepoxide
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Chlordiazepoxide with Sufentanil?
MediHelp rates the interaction as major. Chlordiazepoxide and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Concomitant benzodiazepine and potent opioid use can cause profound sedation, respiratory depression, coma and death. Regulatory agencies have issued boxed warnings for this combination.
How serious is the interaction between Chlordiazepoxide and Sufentanil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve the combination for cases without alternatives, using the lowest doses and shortest duration. Continuously monitor respiration and sedation, with resuscitation equipment available in procedural settings.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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