Drug interactions
Chlordiazepoxide + Ziprasidone
Severity: Moderate
Chlordiazepoxide and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use can increase somnolence and dizziness, and ziprasidone may add orthostatic hypotension. The QT-prolonging effect of ziprasidone is not meaningfully altered by chlordiazepoxide.
What this interaction means in plain words
Chlordiazepoxide and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A potentiation and ziprasidone's receptor antagonism.
What to do
Monitor sedation and orthostatic blood pressure, using the lowest effective doses. Advise patients to avoid alcohol and hazardous activities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Chlordiazepoxide with Ziprasidone?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use can increase somnolence and dizziness, and ziprasidone may add orthostatic hypotension. The QT-prolonging effect of ziprasidone is not meaningfully altered by chlordiazepoxide.
How serious is the interaction between Chlordiazepoxide and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and orthostatic blood pressure, using the lowest effective doses. Advise patients to avoid alcohol and hazardous activities.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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