Drug interactions
Chlordiazepoxide-clidinium + Dextroamphetamine
Severity: Minor
Chlordiazepoxide-clidinium and Dextroamphetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
A sedating benzodiazepine is combined with a stimulant, and the two have opposing effects on alertness. The stimulant may mask sedation without removing impairment of psychomotor performance, and the clinical effect is unpredictable.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Dextroamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Dextroamphetamine belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic CNS effects; no established pharmacokinetic interaction.
What to do
No routine dose change is needed. Advise patients not to rely on the stimulant to offset sedation when driving or operating machinery.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Dextroamphetamine?
MediHelp rates the interaction as minor. Chlordiazepoxide-clidinium and Dextroamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. A sedating benzodiazepine is combined with a stimulant, and the two have opposing effects on alertness. The stimulant may mask sedation without removing impairment of psychomotor performance, and the clinical effect is unpredictable.
How serious is the interaction between Chlordiazepoxide-clidinium and Dextroamphetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Advise patients not to rely on the stimulant to offset sedation when driving or operating machinery.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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