Drug interactions
Chlordiazepoxide-clidinium + Diamorphine
Severity: Major
Chlordiazepoxide-clidinium and Diamorphine: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids with benzodiazepines cause additive CNS and respiratory depression. Profound sedation, respiratory depression, coma and death can result.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Diamorphine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression through GABA-A potentiation and mu-opioid receptor agonism.
What to do
Reserve concomitant use for patients without alternatives, with the lowest effective doses and shortest duration. Monitor closely for respiratory depression and sedation, and consider naloxone availability.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Diamorphine?
MediHelp rates the interaction as major. Chlordiazepoxide-clidinium and Diamorphine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids with benzodiazepines cause additive CNS and respiratory depression. Profound sedation, respiratory depression, coma and death can result.
How serious is the interaction between Chlordiazepoxide-clidinium and Diamorphine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve concomitant use for patients without alternatives, with the lowest effective doses and shortest duration. Monitor closely for respiratory depression and sedation, and consider naloxone availability.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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