Drug interactions
Chlordiazepoxide-clidinium + Diazepam intranasal
Severity: Moderate
Chlordiazepoxide-clidinium and Diazepam intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Two benzodiazepines together increase CNS depression, with excessive sedation, impaired coordination and respiratory depression. The risk is higher in older patients and those with respiratory disease.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Diazepam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic CNS depression via GABA-A receptor potentiation.
What to do
Avoid unnecessary duplication of benzodiazepines and monitor sedation and respiration after rescue doses. Counsel caregivers on warning signs of oversedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Diazepam intranasal?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Diazepam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Two benzodiazepines together increase CNS depression, with excessive sedation, impaired coordination and respiratory depression. The risk is higher in older patients and those with respiratory disease.
How serious is the interaction between Chlordiazepoxide-clidinium and Diazepam intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary duplication of benzodiazepines and monitor sedation and respiration after rescue doses. Counsel caregivers on warning signs of oversedation.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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