Drug interactions
Chlordiazepoxide-clidinium + Diphenhydramine
Severity: Moderate
Chlordiazepoxide-clidinium and Diphenhydramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diphenhydramine is a sedating first-generation antihistamine that enhances benzodiazepine-induced drowsiness and cognitive impairment. Its anticholinergic activity, combined with clidinium, raises the risk of confusion, urinary retention and constipation, especially in elderly patients.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Diphenhydramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Diphenhydramine belongs to Respiratory.
Why it happens
Additive CNS depression and additive antimuscarinic effects.
What to do
Avoid in older adults and use the lowest effective doses otherwise. Monitor for oversedation and anticholinergic toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Diphenhydramine
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Diphenhydramine?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Diphenhydramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diphenhydramine is a sedating first-generation antihistamine that enhances benzodiazepine-induced drowsiness and cognitive impairment. Its anticholinergic activity, combined with clidinium, raises the risk of confusion, urinary retention and constipation, especially in elderly patients.
How serious is the interaction between Chlordiazepoxide-clidinium and Diphenhydramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in older adults and use the lowest effective doses otherwise. Monitor for oversedation and anticholinergic toxicity.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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