Drug interactions
Chlordiazepoxide-clidinium + Disulfiram
Severity: Moderate
Chlordiazepoxide-clidinium and Disulfiram: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disulfiram reduces clearance of chlordiazepoxide, which can increase and prolong its sedative effects. The effect is generally modest but relevant in alcohol-dependent patients receiving both.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Disulfiram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Disulfiram inhibits hepatic oxidative metabolism of chlordiazepoxide.
What to do
Monitor for excess sedation and reduce the chlordiazepoxide dose if needed; lorazepam or oxazepam are alternatives that avoid oxidative metabolism.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Disulfiram?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Disulfiram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Disulfiram reduces clearance of chlordiazepoxide, which can increase and prolong its sedative effects. The effect is generally modest but relevant in alcohol-dependent patients receiving both.
How serious is the interaction between Chlordiazepoxide-clidinium and Disulfiram?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and reduce the chlordiazepoxide dose if needed; lorazepam or oxazepam are alternatives that avoid oxidative metabolism.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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