Drug interactions
Chlordiazepoxide-clidinium + Esketamine intranasal
Severity: Moderate
Chlordiazepoxide-clidinium and Esketamine intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esketamine causes sedation and dissociation, and combining it with a benzodiazepine adds to central nervous system depression. Benzodiazepines may also blunt esketamine's antidepressant effect.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Esketamine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects.
What to do
Monitor sedation and alertness for the observation period after each esketamine dose. Use the lowest effective benzodiazepine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Esketamine intranasal?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Esketamine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esketamine causes sedation and dissociation, and combining it with a benzodiazepine adds to central nervous system depression. Benzodiazepines may also blunt esketamine's antidepressant effect.
How serious is the interaction between Chlordiazepoxide-clidinium and Esketamine intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and alertness for the observation period after each esketamine dose. Use the lowest effective benzodiazepine dose.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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