Drug interactions
Chlordiazepoxide-clidinium + Gabapentin
Severity: Major
Chlordiazepoxide-clidinium and Gabapentin: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzodiazepines combined with gabapentin produce additive CNS and respiratory depression. Profound sedation, respiratory depression and falls may occur, especially in older adults or those with lung disease.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Gabapentin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Gabapentin belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS and respiratory depression.
What to do
Use the lowest effective doses and shortest duration. Monitor for sedation and respiratory depression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Gabapentin
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Gabapentin?
MediHelp rates the interaction as major. Chlordiazepoxide-clidinium and Gabapentin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Benzodiazepines combined with gabapentin produce additive CNS and respiratory depression. Profound sedation, respiratory depression and falls may occur, especially in older adults or those with lung disease.
How serious is the interaction between Chlordiazepoxide-clidinium and Gabapentin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and shortest duration. Monitor for sedation and respiratory depression.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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