Drug interactions
Chlordiazepoxide-clidinium + Ketamine
Severity: Moderate
Chlordiazepoxide-clidinium and Ketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketamine combined with a benzodiazepine can increase sedation and may cause respiratory depression, although benzodiazepines are sometimes used to reduce ketamine emergence reactions. Monitoring is required when both are given.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Ketamine belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation and NMDA receptor antagonism.
What to do
Titrate doses to effect and monitor respiratory status and sedation level. Ensure airway support is available during procedural use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Ketamine
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Ketamine?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketamine combined with a benzodiazepine can increase sedation and may cause respiratory depression, although benzodiazepines are sometimes used to reduce ketamine emergence reactions. Monitoring is required when both are given.
How serious is the interaction between Chlordiazepoxide-clidinium and Ketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate doses to effect and monitor respiratory status and sedation level. Ensure airway support is available during procedural use.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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