Drug interactions
Chlordiazepoxide-clidinium + Lofepramine
Severity: Moderate
Chlordiazepoxide-clidinium and Lofepramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine is a sedating tricyclic antidepressant, and with chlordiazepoxide it can increase drowsiness and psychomotor impairment. The clidinium component may also add anticholinergic effects.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and anticholinergic effects.
What to do
Monitor for sedation, confusion and anticholinergic effects, and advise caution with driving. Reduce doses if excess sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Lofepramine?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofepramine is a sedating tricyclic antidepressant, and with chlordiazepoxide it can increase drowsiness and psychomotor impairment. The clidinium component may also add anticholinergic effects.
How serious is the interaction between Chlordiazepoxide-clidinium and Lofepramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, confusion and anticholinergic effects, and advise caution with driving. Reduce doses if excess sedation occurs.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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