Drug interactions
Chlordiazepoxide-clidinium + Marijuana
Severity: Moderate
Chlordiazepoxide-clidinium and Marijuana: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabis can add to the sedative and psychomotor effects of chlordiazepoxide, impairing alertness, memory and driving ability.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Marijuana can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via cannabinoid and GABAergic effects.
What to do
Counsel patients to avoid driving or hazardous tasks and monitor for excess sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Marijuana?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Marijuana can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabis can add to the sedative and psychomotor effects of chlordiazepoxide, impairing alertness, memory and driving ability.
How serious is the interaction between Chlordiazepoxide-clidinium and Marijuana?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to avoid driving or hazardous tasks and monitor for excess sedation.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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