Drug interactions
Chlordiazepoxide-clidinium + Metoclopramide intranasal
Severity: Moderate
Chlordiazepoxide-clidinium and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide can cause sedation and extrapyramidal effects, and CNS depressants such as chlordiazepoxide may add to drowsiness. Clidinium's anticholinergic action also opposes metoclopramide's prokinetic effect.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, plus pharmacodynamic antagonism of gastrointestinal motility by clidinium.
What to do
Monitor for excess drowsiness and warn patients about driving. Avoid using prokinetic metoclopramide together with the anticholinergic component when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide can cause sedation and extrapyramidal effects, and CNS depressants such as chlordiazepoxide may add to drowsiness. Clidinium's anticholinergic action also opposes metoclopramide's prokinetic effect.
How serious is the interaction between Chlordiazepoxide-clidinium and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess drowsiness and warn patients about driving. Avoid using prokinetic metoclopramide together with the anticholinergic component when possible.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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