Drug interactions
Chlordiazepoxide-clidinium + Midazolam intranasal
Severity: Major
Chlordiazepoxide-clidinium and Midazolam intranasal: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Two benzodiazepines used together produce additive sedation and respiratory depression, which can lead to hypoventilation, apnea and prolonged drug effect.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Midazolam intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive GABA-A receptor-mediated CNS and respiratory depression.
What to do
Monitor respiratory rate and oxygen saturation closely and use the lowest effective midazolam dose. Ensure resuscitation equipment is available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Midazolam intranasal?
MediHelp rates the interaction as major. Chlordiazepoxide-clidinium and Midazolam intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Two benzodiazepines used together produce additive sedation and respiratory depression, which can lead to hypoventilation, apnea and prolonged drug effect.
How serious is the interaction between Chlordiazepoxide-clidinium and Midazolam intranasal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory rate and oxygen saturation closely and use the lowest effective midazolam dose. Ensure resuscitation equipment is available.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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