Drug interactions
Chlordiazepoxide-clidinium + Nafcillin
Severity: Minor
Chlordiazepoxide-clidinium and Nafcillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin can induce CYP3A4 and may lower chlordiazepoxide exposure, possibly reducing anxiolytic or withdrawal-suppressing effect. The effect is generally modest and develops over days of nafcillin therapy.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Nafcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Induction of CYP3A4-mediated hepatic metabolism of chlordiazepoxide by nafcillin.
What to do
Monitor for reduced benzodiazepine effect during nafcillin therapy and adjust the dose if needed. Reassess the dose when nafcillin is stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Nafcillin?
MediHelp rates the interaction as minor. Chlordiazepoxide-clidinium and Nafcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nafcillin can induce CYP3A4 and may lower chlordiazepoxide exposure, possibly reducing anxiolytic or withdrawal-suppressing effect. The effect is generally modest and develops over days of nafcillin therapy.
How serious is the interaction between Chlordiazepoxide-clidinium and Nafcillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced benzodiazepine effect during nafcillin therapy and adjust the dose if needed. Reassess the dose when nafcillin is stopped.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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