Drug interactions
Chlordiazepoxide-clidinium + Olanzapine / samidorphan
Severity: Moderate
Chlordiazepoxide-clidinium and Olanzapine / samidorphan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a benzodiazepine with olanzapine increases sedation and can worsen orthostatic hypotension. Respiratory depression and syncope have been reported when olanzapine is combined with benzodiazepines, mainly parenteral forms.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and hypotensive effects, with alpha-1 adrenergic blockade from olanzapine.
What to do
Monitor sedation, blood pressure and orthostatic symptoms, and start with lower doses in older or frail patients. Avoid alcohol and other CNS depressants.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Olanzapine / samidorphan?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a benzodiazepine with olanzapine increases sedation and can worsen orthostatic hypotension. Respiratory depression and syncope have been reported when olanzapine is combined with benzodiazepines, mainly parenteral forms.
How serious is the interaction between Chlordiazepoxide-clidinium and Olanzapine / samidorphan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure and orthostatic symptoms, and start with lower doses in older or frail patients. Avoid alcohol and other CNS depressants.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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