Drug interactions
Chlordiazepoxide-clidinium + Olanzapine
Severity: Moderate
Chlordiazepoxide-clidinium and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine combined with a benzodiazepine increases sedation and may cause orthostatic hypotension. Cardiorespiratory depression has been reported with parenteral olanzapine given with benzodiazepines.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Olanzapine belongs to Central Nervous System.
Why it happens
Additive CNS depression, and olanzapine's anticholinergic activity adds to clidinium.
What to do
Avoid giving intramuscular olanzapine and parenteral benzodiazepines close together; monitor sedation, blood pressure, and respiration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Olanzapine
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Olanzapine?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine combined with a benzodiazepine increases sedation and may cause orthostatic hypotension. Cardiorespiratory depression has been reported with parenteral olanzapine given with benzodiazepines.
How serious is the interaction between Chlordiazepoxide-clidinium and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving intramuscular olanzapine and parenteral benzodiazepines close together; monitor sedation, blood pressure, and respiration.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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