Drug interactions
Chlordiazepoxide-clidinium + Orphenadrine
Severity: Moderate
Chlordiazepoxide-clidinium and Orphenadrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orphenadrine is a sedating anticholinergic muscle relaxant. Together with chlordiazepoxide it increases drowsiness and confusion, and clidinium adds further anticholinergic burden (dry mouth, urinary retention, constipation).
What this interaction means in plain words
Chlordiazepoxide-clidinium and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and additive antimuscarinic effects.
What to do
Monitor for oversedation, confusion and anticholinergic effects, particularly in older adults. Use the lowest effective doses and avoid driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Orphenadrine?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orphenadrine is a sedating anticholinergic muscle relaxant. Together with chlordiazepoxide it increases drowsiness and confusion, and clidinium adds further anticholinergic burden (dry mouth, urinary retention, constipation).
How serious is the interaction between Chlordiazepoxide-clidinium and Orphenadrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation, confusion and anticholinergic effects, particularly in older adults. Use the lowest effective doses and avoid driving.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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