Drug interactions
Chlordiazepoxide-clidinium + Pentobarbital
Severity: Major
Chlordiazepoxide-clidinium and Pentobarbital: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates and benzodiazepines together produce marked additive sedation and respiratory depression. Pentobarbital also induces hepatic enzymes and may lower chlordiazepoxide levels over time.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Pentobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive GABA-A mediated CNS depression, with enzyme induction by pentobarbital.
What to do
Avoid routine combination; if used, reduce doses and monitor respiration, sedation level and blood pressure. Reassess benzodiazepine requirements during prolonged barbiturate use.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Pentobarbital?
MediHelp rates the interaction as major. Chlordiazepoxide-clidinium and Pentobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Barbiturates and benzodiazepines together produce marked additive sedation and respiratory depression. Pentobarbital also induces hepatic enzymes and may lower chlordiazepoxide levels over time.
How serious is the interaction between Chlordiazepoxide-clidinium and Pentobarbital?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine combination; if used, reduce doses and monitor respiration, sedation level and blood pressure. Reassess benzodiazepine requirements during prolonged barbiturate use.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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