Drug interactions
Chlordiazepoxide-clidinium + Phenytoin
Severity: Moderate
Chlordiazepoxide-clidinium and Phenytoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin induces hepatic enzymes and may lower chlordiazepoxide concentrations, reducing its effect. Benzodiazepines can also variably alter phenytoin levels, with reports of both increases and decreases.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Phenytoin belongs to Central Nervous System.
Why it happens
Phenytoin induces CYP enzymes including CYP3A4, increasing chlordiazepoxide clearance.
What to do
Monitor clinical response to chlordiazepoxide and consider dose adjustment. Check phenytoin levels when starting or stopping the benzodiazepine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Phenytoin?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenytoin induces hepatic enzymes and may lower chlordiazepoxide concentrations, reducing its effect. Benzodiazepines can also variably alter phenytoin levels, with reports of both increases and decreases.
How serious is the interaction between Chlordiazepoxide-clidinium and Phenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to chlordiazepoxide and consider dose adjustment. Check phenytoin levels when starting or stopping the benzodiazepine.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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