Drug interactions
Chlordiazepoxide-clidinium + Pimozide
Severity: Moderate
Chlordiazepoxide-clidinium and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimozide can cause sedation, and with chlordiazepoxide the CNS depressant effects are additive. Pimozide also carries QT-prolongation risk, so overall monitoring is important in these patients.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Pimozide belongs to Central Nervous System.
Why it happens
Additive CNS depression via D2 blockade and GABA-A potentiation.
What to do
Monitor for oversedation and impaired psychomotor function, and review other QT-prolonging or CNS-depressant drugs. Use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Pimozide?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pimozide can cause sedation, and with chlordiazepoxide the CNS depressant effects are additive. Pimozide also carries QT-prolongation risk, so overall monitoring is important in these patients.
How serious is the interaction between Chlordiazepoxide-clidinium and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and impaired psychomotor function, and review other QT-prolonging or CNS-depressant drugs. Use the lowest effective doses.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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