Drug interactions
Chlordiazepoxide-clidinium + Protriptyline
Severity: Moderate
Chlordiazepoxide-clidinium and Protriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protriptyline is a tricyclic antidepressant with anticholinergic properties. With chlordiazepoxide-clidinium, additive sedation, psychomotor impairment and anticholinergic effects such as dry mouth, constipation and urinary retention may occur.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and additive antimuscarinic activity.
What to do
Monitor for oversedation and anticholinergic toxicity, particularly in older adults, and use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Protriptyline?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protriptyline is a tricyclic antidepressant with anticholinergic properties. With chlordiazepoxide-clidinium, additive sedation, psychomotor impairment and anticholinergic effects such as dry mouth, constipation and urinary retention may occur.
How serious is the interaction between Chlordiazepoxide-clidinium and Protriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and anticholinergic toxicity, particularly in older adults, and use the lowest effective doses.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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