Drug interactions
Chlordiazepoxide-clidinium + Rifampin
Severity: Moderate
Chlordiazepoxide-clidinium and Rifampin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin strongly induces hepatic enzymes and can substantially lower chlordiazepoxide exposure, reducing its anxiolytic or anticonvulsant effect and potentially causing withdrawal symptoms.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 and other metabolic enzymes by rifampin, increasing chlordiazepoxide clearance.
What to do
Monitor for loss of benzodiazepine effect and increase the dose if needed. Reduce the dose again after rifampin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Rifampin?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin strongly induces hepatic enzymes and can substantially lower chlordiazepoxide exposure, reducing its anxiolytic or anticonvulsant effect and potentially causing withdrawal symptoms.
How serious is the interaction between Chlordiazepoxide-clidinium and Rifampin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of benzodiazepine effect and increase the dose if needed. Reduce the dose again after rifampin is stopped.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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