Drug interactions
Chlordiazepoxide-clidinium + Valerian
Severity: Moderate
Chlordiazepoxide-clidinium and Valerian: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valerian has sedative properties and may add to the CNS depression caused by chlordiazepoxide. This may cause drowsiness and impaired psychomotor performance.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Valerian can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sedation, possibly via GABAergic activity of valerian constituents.
What to do
Advise patients to avoid valerian while taking the benzodiazepine, or monitor for excess sedation and caution against driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Valerian?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Valerian can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valerian has sedative properties and may add to the CNS depression caused by chlordiazepoxide. This may cause drowsiness and impaired psychomotor performance.
How serious is the interaction between Chlordiazepoxide-clidinium and Valerian?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid valerian while taking the benzodiazepine, or monitor for excess sedation and caution against driving.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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