Drug interactions
Chlordiazepoxide-clidinium + Zolpidem
Severity: Moderate
Chlordiazepoxide-clidinium and Zolpidem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a benzodiazepine with zolpidem produces additive central nervous system depression. This raises the risk of excessive sedation, impaired coordination, falls, complex sleep behaviours and next-day impairment, especially in older adults.
What this interaction means in plain words
Chlordiazepoxide-clidinium and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract; Zolpidem belongs to Central Nervous System.
Why it happens
Both drugs enhance GABA-A receptor mediated inhibition, giving additive pharmacodynamic CNS depression.
What to do
Avoid routine concurrent use of two sedative-hypnotics; if unavoidable use the lowest effective doses for the shortest time. Counsel patients to avoid alcohol and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
Other interactions of Zolpidem
Frequently asked questions
Can I take Chlordiazepoxide-clidinium with Zolpidem?
MediHelp rates the interaction as moderate. Chlordiazepoxide-clidinium and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a benzodiazepine with zolpidem produces additive central nervous system depression. This raises the risk of excessive sedation, impaired coordination, falls, complex sleep behaviours and next-day impairment, especially in older adults.
How serious is the interaction between Chlordiazepoxide-clidinium and Zolpidem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine concurrent use of two sedative-hypnotics; if unavoidable use the lowest effective doses for the shortest time. Counsel patients to avoid alcohol and driving.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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