Drug interactions
Chloroprocaine + Propranolol
Severity: Minor
Chloroprocaine and Propranolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloroprocaine is generally not formulated with epinephrine, so the interaction is relevant only if a vasoconstrictor is added. Non-selective beta-blockade can then cause hypertension and bradycardia.
What this interaction means in plain words
Chloroprocaine and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chloroprocaine belongs to Central Nervous System; Propranolol belongs to Cardiovascular.
Why it happens
If epinephrine is added, propranolol leaves alpha-mediated vasoconstriction unopposed.
What to do
Do not stop propranolol; monitor blood pressure and heart rate if an epinephrine-containing preparation is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Other interactions of Chloroprocaine
- Chloroprocaine + Dapsone Moderate
- Chloroprocaine + Timolol Moderate
- Chloroprocaine + Nadolol Minor
Frequently asked questions
Can I take Chloroprocaine with Propranolol?
MediHelp rates the interaction as minor. Chloroprocaine and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chloroprocaine is generally not formulated with epinephrine, so the interaction is relevant only if a vasoconstrictor is added. Non-selective beta-blockade can then cause hypertension and bradycardia.
How serious is the interaction between Chloroprocaine and Propranolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not stop propranolol; monitor blood pressure and heart rate if an epinephrine-containing preparation is used.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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