Drug interactions
Chloroprocaine + Timolol
Severity: Moderate
Chloroprocaine and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
If chloroprocaine is given with epinephrine, nonselective beta-blockade such as timolol can leave alpha-mediated pressor effects unopposed. This can produce hypertension with reflex bradycardia.
What this interaction means in plain words
Chloroprocaine and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloroprocaine belongs to Central Nervous System; Timolol belongs to Cardiovascular.
Why it happens
Timolol blocks beta-2 vasodilation, leaving epinephrine's alpha-mediated vasoconstriction unopposed.
What to do
Continue the beta-blocker perioperatively, use the lowest epinephrine dose or an epinephrine-free preparation, and monitor blood pressure and heart rate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Other interactions of Chloroprocaine
- Chloroprocaine + Dapsone Moderate
- Chloroprocaine + Nadolol Minor
- Chloroprocaine + Propranolol Minor
Frequently asked questions
Can I take Chloroprocaine with Timolol?
MediHelp rates the interaction as moderate. Chloroprocaine and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. If chloroprocaine is given with epinephrine, nonselective beta-blockade such as timolol can leave alpha-mediated pressor effects unopposed. This can produce hypertension with reflex bradycardia.
How serious is the interaction between Chloroprocaine and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Continue the beta-blocker perioperatively, use the lowest epinephrine dose or an epinephrine-free preparation, and monitor blood pressure and heart rate.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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