Drug interactions
Chloroprocaine + Dapsone
Severity: Moderate
Chloroprocaine and Dapsone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both local anesthetics and dapsone can oxidize hemoglobin to methemoglobin. Used together, they may increase the risk of clinically significant methemoglobinemia, causing cyanosis, dyspnea, and tissue hypoxia. Risk is higher in patients with G6PD deficiency or existing anemia.
What this interaction means in plain words
Chloroprocaine and Dapsone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloroprocaine belongs to Central Nervous System; Dapsone belongs to Anti Bacterial.
Why it happens
Additive oxidant stress on hemoglobin from the two drugs leads to formation of methemoglobin.
What to do
Use the lowest effective dose of chloroprocaine and watch for cyanosis, low pulse oximetry readings, and dyspnea. Confirm with co-oximetry and treat with methylene blue if symptomatic, unless G6PD deficiency is present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloroprocaine
- Chloroprocaine + Timolol Moderate
- Chloroprocaine + Nadolol Minor
- Chloroprocaine + Propranolol Minor
Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Frequently asked questions
Can I take Chloroprocaine with Dapsone?
MediHelp rates the interaction as moderate. Chloroprocaine and Dapsone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both local anesthetics and dapsone can oxidize hemoglobin to methemoglobin. Used together, they may increase the risk of clinically significant methemoglobinemia, causing cyanosis, dyspnea, and tissue hypoxia. Risk is higher in patients with G6PD deficiency or existing anemia.
How serious is the interaction between Chloroprocaine and Dapsone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective dose of chloroprocaine and watch for cyanosis, low pulse oximetry readings, and dyspnea. Confirm with co-oximetry and treat with methylene blue if symptomatic, unless G6PD deficiency is present.
What other medicines interact with Chloroprocaine?
MediHelp also lists interactions of Chloroprocaine with, for example, Timolol, Nadolol, Propranolol. The full list is on the Chloroprocaine page.
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