Drug interactions
Chlorothiazide + Dexamethasone-tobramycin
Severity: Moderate
Chlorothiazide and Dexamethasone-tobramycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both corticosteroids and thiazide diuretics promote urinary potassium loss, so together they can cause hypokalemia. This is relevant mainly with systemic steroids.
What this interaction means in plain words
Chlorothiazide and Dexamethasone-tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorothiazide belongs to Cardiovascular; Dexamethasone-tobramycin belongs to Anti Bacterial.
Why it happens
Additive renal potassium wasting from thiazide action and glucocorticoid mineralocorticoid effects.
What to do
Monitor serum potassium during systemic steroid use and supplement potassium as needed. Take extra care in patients with heart disease or on digoxin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Dexamethasone-tobramycin?
MediHelp rates the interaction as moderate. Chlorothiazide and Dexamethasone-tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both corticosteroids and thiazide diuretics promote urinary potassium loss, so together they can cause hypokalemia. This is relevant mainly with systemic steroids.
How serious is the interaction between Chlorothiazide and Dexamethasone-tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium during systemic steroid use and supplement potassium as needed. Take extra care in patients with heart disease or on digoxin.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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